Vertical transmission of SARS-CoV-2 delta-variant in a preterm infant.
BMC Infect Dis
; 24(1): 537, 2024 May 28.
Article
in En
| MEDLINE
| ID: mdl-38807052
ABSTRACT
BACKGROUND:
As SARS-CoV-2 continues to be relevant and cause illnesses, the effect of emerging virus variants on perinatal health remains to be elucidated. It was demonstrated that vertical transmission of SARS-CoV-2 is a relatively rare event in the original SARS-CoV-2 strain. However, very few reports describe vertical transmission related to the delta-variant. CASE PRESENTATION We report a case of a preterm male neonate born to a mother with positive SARS-CoV-2 and mild respiratory complications. The neonate was born by cesarean section due to fetal distress. The rupture of the amniotic membrane was at delivery. The neonate had expected prematurity-related complications. His nasopharyngeal swabs for RT-PCR were positive from birth till three weeks of age. RT-ddPCR of the Placenta showed a high load of the SARS-CoV-2 virus with subgenomic viral RNA. RNAscope technique demonstrated both the positive strand of the S gene and the orf1ab negative strand. Detection of subgenomic RNA and the orf1ab negative strand indicats active viral replication in the placenta.CONCLUSIONS:
Our report demonstrates active viral replication of the SARS-CoV-2 delta-variant in the placenta associated with vertical transmission in a preterm infant.Key words
Full text:
1
Database:
MEDLINE
Main subject:
Pregnancy Complications, Infectious
/
Infant, Premature
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Infectious Disease Transmission, Vertical
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SARS-CoV-2
/
COVID-19
Limits:
Adult
/
Female
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Humans
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Male
/
Newborn
/
Pregnancy
Language:
En
Journal:
BMC Infect Dis
Journal subject:
DOENCAS TRANSMISSIVEIS
Year:
2024
Type:
Article
Affiliation country:
United States