Immobilising an acid-cleavable dimeric phthalocyanine on gold nanobipyramids for intracellular pH detection and photodynamic elimination of cancer cells.
Analyst
; 149(12): 3288-3292, 2024 Jun 10.
Article
in En
| MEDLINE
| ID: mdl-38808583
ABSTRACT
An acetal-linked dimeric phthalocyanine has been synthesised and immobilised on the surface of gold nanobipyramids. The resulting nanocomposite serves as a highly sensitive probe for intracellular pH through its acid-responsive fluorescence and surface-enhanced Raman scattering signals. The phthalocyanine units released in the acidic intracellular environment can also effectively eliminate the cancer cells upon light irradiation, rendering this simple fabricated nanosystem a bimodal and bifunctional theranostic agent.
Full text:
1
Database:
MEDLINE
Main subject:
Photochemotherapy
/
Isoindoles
/
Gold
/
Indoles
Limits:
Humans
Language:
En
Journal:
Analyst
Year:
2024
Type:
Article
Affiliation country:
China