Nuclear receptor Nur77 and Yin-Yang 1 synergistically increase mitochondrial abundance and activity in macrophages.
FEBS Lett
; 598(14): 1715-1729, 2024 Jul.
Article
in En
| MEDLINE
| ID: mdl-38825601
ABSTRACT
Mitochondrial biogenesis requires precise regulation of both mitochondrial-encoded and nuclear-encoded genes. Nuclear receptor Nur77 is known to regulate mitochondrial metabolism in macrophages and skeletal muscle. Here, we compared genome-wide Nur77 binding site and target gene expression in these two cell types, which revealed conserved regulation of mitochondrial genes and enrichment of motifs for the transcription factor Yin-Yang 1 (YY1). We show that Nur77 and YY1 interact, that YY1 increases Nur77 activity, and that their binding sites are co-enriched at mitochondrial ribosomal protein gene loci in macrophages. Nur77 and YY1 co-expression synergistically increases Mrpl1 expression as well as mitochondrial abundance and activity in macrophages but not skeletal muscle. As such, we identify a macrophage-specific Nur77-YY1 interaction that enhances mitochondrial metabolism.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
YY1 Transcription Factor
/
Nuclear Receptor Subfamily 4, Group A, Member 1
/
Macrophages
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Mitochondria
Limits:
Animals
/
Humans
Language:
En
Journal:
FEBS Lett
Year:
2024
Type:
Article