Not just binary: embracing the complexity of nuclear division dynamics.
Nucleus
; 15(1): 2360601, 2024 Dec.
Article
in En
| MEDLINE
| ID: mdl-38842147
ABSTRACT
Cell division presents a challenge for eukaryotic cells how can chromosomes effectively segregate within the confines of a membranous nuclear compartment? Different organisms have evolved diverse solutions by modulating the degree of nuclear compartmentalization, ranging from complete nuclear envelope breakdown to complete maintenance of nuclear compartmentalization via nuclear envelope expansion. Many intermediate forms exist between these extremes, suggesting that nuclear dynamics during cell division are surprisingly plastic. In this review, we highlight the evolutionary diversity of nuclear divisions, focusing on two defining characteristics (1) chromosome compartmentalization and (2) nucleocytoplasmic transport. Further, we highlight recent evidence that nuclear behavior during division can vary within different cellular contexts in the same organism. The variation observed within and between organisms underscores the dynamic evolution of nuclear divisions tailored to specific contexts and cellular requirements. In-depth investigation of diverse nuclear divisions will enhance our understanding of the nucleus, both in physiological and pathological states.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Cell Nucleus Division
Limits:
Animals
/
Humans
Language:
En
Journal:
Nucleus
Year:
2024
Type:
Article
Affiliation country:
United States