γδ T cells and the PD-1/PD-L1 axis: a love-hate relationship in the tumor microenvironment.
J Transl Med
; 22(1): 553, 2024 Jun 10.
Article
in En
| MEDLINE
| ID: mdl-38858763
ABSTRACT
Gamma delta (γδ) T cells demonstrate strong cytotoxicity against diverse cancer cell types in an MHC-independent manner, rendering them promising contenders for cancer therapy. Although amplification and adoptive transfer of γδ T cells are being evaluated in the clinic, their therapeutic efficacy remains unsatisfactory, primarily due to the influence of the immunosuppressive tumor microenvironment (TME). Currently, the utilization of targeted therapeutic antibodies against inhibitory immune checkpoint (ICP) molecules is a viable approach to counteract the immunosuppressive consequences of the TME. Notably, PD-1/PD-L1 checkpoint inhibitors are considered primary treatment options for diverse malignancies, with the objective of preserving the response of αß T cells. However, γδ T cells also infiltrate various human cancers and are important participants in cancer immunity, thereby influencing patient prognosis. Hence, it is imperative to comprehend the reciprocal impact of the PD-1/PD-L1 axis on γδ T cells. This understanding can serve as a therapeutic foundation for improving γδ T cells adoptive transfer therapy and may offer a novel avenue for future combined immunotherapeutic approaches.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Tumor Microenvironment
/
B7-H1 Antigen
/
Programmed Cell Death 1 Receptor
Limits:
Animals
/
Humans
Language:
En
Journal:
J Transl Med
Year:
2024
Type:
Article
Affiliation country:
China