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Biosurfactant complexed with arginine has antibiofilm activity against methicillin-resistant Staphylococcus aureus.
Dias Barroso, Fatima Daiana; da Silva, Lisandra Juvêncio; Queiroz, Helaine Almeida; do Amaral Valente Sá, Lívia Gurgel; da Silva, Anderson Ramos; da Silva, Cecília Rocha; de Andrade Neto, João Batista; Cavalcanti, Bruno Coêlho; de Moraes, Manoel Odorico; Pinazo, Aurora; Pérez, Lourdes; Nobre Júnior, Hélio Vitoriano.
Affiliation
  • Dias Barroso FD; Drug Research & Development Center, Federal University of Ceará, Fortaleza, CE, Brazil.
  • da Silva LJ; School of Pharmacy, Laboratory of Bioprospection of Antimicrobial Molecules (LABIMAN), Federal University of Ceará, Fortaleza, CE, Brazil.
  • Queiroz HA; Drug Research & Development Center, Federal University of Ceará, Fortaleza, CE, Brazil.
  • do Amaral Valente Sá LG; School of Pharmacy, Laboratory of Bioprospection of Antimicrobial Molecules (LABIMAN), Federal University of Ceará, Fortaleza, CE, Brazil.
  • da Silva AR; Drug Research & Development Center, Federal University of Ceará, Fortaleza, CE, Brazil.
  • da Silva CR; School of Pharmacy, Laboratory of Bioprospection of Antimicrobial Molecules (LABIMAN), Federal University of Ceará, Fortaleza, CE, Brazil.
  • de Andrade Neto JB; Drug Research & Development Center, Federal University of Ceará, Fortaleza, CE, Brazil.
  • Cavalcanti BC; School of Pharmacy, Laboratory of Bioprospection of Antimicrobial Molecules (LABIMAN), Federal University of Ceará, Fortaleza, CE, Brazil.
  • de Moraes MO; Christus University Center (UNICHRISTUS), Fortaleza, CE, Brazil.
  • Pinazo A; Department of Surfactants & Nanobiotechnology, IQAC-CSIC, Barcelona, Spain.
  • Pérez L; Drug Research & Development Center, Federal University of Ceará, Fortaleza, CE, Brazil.
  • Nobre Júnior HV; School of Pharmacy, Laboratory of Bioprospection of Antimicrobial Molecules (LABIMAN), Federal University of Ceará, Fortaleza, CE, Brazil.
Future Microbiol ; 19(8): 667-679, 2024.
Article in En | MEDLINE | ID: mdl-38864708
ABSTRACT

Aim:

The present study investigated the antimicrobial effectiveness of a rhamnolipid complexed with arginine (RLMIX_Arg) against planktonic cells and biofilms of methicillin-resistant Staphylococcus aureus (MRSA).

Methodology:

Susceptibility testing was performed using the Clinical & Laboratory Standards Institute protocol M07-A10, checkerboard test, biofilm in plates and catheters and flow cytometry were used.

Result:

RLMIX_Arg has bactericidal and synergistic activity with oxacillin. RLMIX_Arg inhibits the formation of MRSA biofilms on plates at sub-inhibitory concentrations and has antibiofilm action against MRSA in peripheral venous catheters. Catheters impregnated with RLMIX_Arg reduce the formation of MRSA biofilms.

Conclusion:

RLMIX_Arg exhibits potential for application in preventing infections related to methicillin-resistant S. aureus biofilms.
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Full text: 1 Database: MEDLINE Main subject: Arginine / Surface-Active Agents / Microbial Sensitivity Tests / Biofilms / Methicillin-Resistant Staphylococcus aureus / Anti-Bacterial Agents Limits: Humans Language: En Journal: Future Microbiol Journal subject: MICROBIOLOGIA Year: 2024 Type: Article Affiliation country: Brazil
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Full text: 1 Database: MEDLINE Main subject: Arginine / Surface-Active Agents / Microbial Sensitivity Tests / Biofilms / Methicillin-Resistant Staphylococcus aureus / Anti-Bacterial Agents Limits: Humans Language: En Journal: Future Microbiol Journal subject: MICROBIOLOGIA Year: 2024 Type: Article Affiliation country: Brazil