Effectiveness of fractional erbium-YAG laser, microneedling, platelet-rich plasma in localized stable vitiligo patients: randomized clinical trial.
Arch Dermatol Res
; 316(7): 399, 2024 Jun 15.
Article
in En
| MEDLINE
| ID: mdl-38878236
ABSTRACT
Vitiligo is considered an autoimmune disease, and its treatment is challenging. We assessed and compared the effect of fractional erbiumyttrium-aluminum-garnet (ErYAG) laser-assisted delivery of platelet-rich plasma versus microneedling (Mn) with platelet-rich plasma (PRP) in enhancing skin repigmentation in localized stable vitiligo patients. In total, 40 patients with localized stable vitiligo were selected in a random manner into two similar groups (20 each). Group (A) was subjected to fractional ErYAG laser combined with platelet-rich plasma and Group (B) was subjected to microneedling combined with platelet-rich plasma. The procedure was repeated every 2 weeks for up to 6 months. Each individual was assessed clinically utilizing Vitiligo Area Scoring Index (VASI). Fractional ErYAG + PRP group achieved better pigmentation100% (excellent 30%, very good 15%, good 30% and satisfactory 25%) which is comparable to Mn + PRP where 80% of cases demonstrate repigmentation (20% very good, 10% good and 50% mild). When comparing the VASI scores for both groups after therapy to the baseline VASI, there was a statistically significant decrease [p = 0.001 for group(A) and 0.003 for group(B)]. Regarding the treatment side effects, there was significantly (p = 0.048) side effects among cases treated with microneedling group(B) (25%) than those fractional ErYag laser therapy group(A) (5%). Both forms of therapy demonstrated induction of repigmentation of vitiligo, but fractional ErYAG laser efficacy is greater when combined with platelet-rich plasma.Clinical trials.gov identifier NCT05511493.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Vitiligo
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Skin Pigmentation
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Platelet-Rich Plasma
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Lasers, Solid-State
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Needles
Limits:
Adolescent
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Adult
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Female
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Humans
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Male
/
Middle aged
Language:
En
Journal:
Arch Dermatol Res
Year:
2024
Type:
Article
Affiliation country:
Egypt