New facets in the chromatin-based regulation of genome maintenance.
DNA Repair (Amst)
; 140: 103702, 2024 Aug.
Article
in En
| MEDLINE
| ID: mdl-38878564
ABSTRACT
The maintenance of genome integrity by DNA damage response machineries is key to protect cells against pathological development. In cell nuclei, these genome maintenance machineries operate in the context of chromatin, where the DNA wraps around histone proteins. Here, we review recent findings illustrating how the chromatin substrate modulates genome maintenance mechanisms, focusing on the regulatory role of histone variants and post-translational modifications. In particular, we discuss how the pre-existing chromatin landscape impacts DNA damage formation and guides DNA repair pathway choice, and how DNA damage-induced chromatin alterations control DNA damage signaling and repair, and DNA damage segregation through cell divisions. We also highlight that pathological alterations of histone proteins may trigger genome instability by impairing chromosome segregation and DNA repair, thus defining new oncogenic mechanisms and opening up therapeutic options.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
DNA Damage
/
Chromatin
/
Histones
/
Protein Processing, Post-Translational
/
Genomic Instability
/
DNA Repair
Limits:
Animals
/
Humans
Language:
En
Journal:
DNA Repair (Amst)
Journal subject:
BIOLOGIA MOLECULAR
/
BIOQUIMICA
Year:
2024
Type:
Article