Dependence of rhythmic activity and oddball effects in the rat cortex on the depth of sedation during dissociative anesthesia.
Cereb Cortex
; 34(6)2024 Jun 04.
Article
in En
| MEDLINE
| ID: mdl-38879757
ABSTRACT
The reactions to novelty manifesting in mismatch negativity in the rat brain were studied. During dissociative anesthesia, mismatch negativity-like waves were recorded from the somatosensory cortex using an epidural 32-electrode array. Experimental animals 7 wild-type Wistar rats and 3 transgenic rats. During high-dose anesthesia, deviant 1,500 Hz tones were presented randomly among many standard 1,000 Hz tones in the oddball paradigm. "Deviant minus standard_before_deviant" difference waves were calculated using both the classical method of Naatanen and method of cross-correlation of sub-averages. Both methods gave consistent results:
an early phasic component of the N40 and later N100 to 200 (mismatch negativity itself) tonic component. The gamma and delta rhythms power and the frequency of down-states (suppressed activity periods) were assessed. In all rats, the amplitude of tonic component grew with increasing sedation depth. At the same time, a decrease in gamma power with a simultaneous increase in delta power and the frequency of down-states. The earlier phasic frontocentral component is associated with deviance detection, while the later tonic one over the auditory cortex reflects the orienting reaction. Under anesthesia, this slow mismatch negativity-like wave most likely reflects the tendency of the system to respond to any influences with delta waves, K-complexes and down-states, or produce them spontaneously.Key words
Full text:
1
Database:
MEDLINE
Main subject:
Rats, Wistar
Limits:
Animals
Language:
En
Journal:
Cereb Cortex
Journal subject:
CEREBRO
Year:
2024
Type:
Article
Affiliation country:
Russia