Coagulation abnormalities associated with CAR-T-cell therapy in haematological malignancies: A review.
Br J Haematol
; 205(2): 420-428, 2024 Aug.
Article
in En
| MEDLINE
| ID: mdl-38887101
ABSTRACT
Chimeric antigen receptor (CAR)-T-cell therapy has demonstrated considerable efficacy and safety in the treatment of patients with relapsed/refractory haematological malignancies. Owing to significant advances, CAR-T-cell therapeutic modality has undergone substantial shifts in its clinical application. Coagulation abnormalities, which are prevalent complications in CAR-T-cell therapy, can range in severity from simple abnormalities in coagulation parameters to serious haemorrhage or disseminated intravascular coagulation associated with life-threatening multiorgan dysfunction. Nonetheless, there is a lack of a comprehensive overview concerning the coagulation abnormalities associated with CAR-T-cell therapy. With an aim to attract heightened clinical focus and to enhance the safety of CAR-T-cell therapy, this review presents the characteristics of the coagulation abnormalities associated with CAR-T-cell therapy, including clinical manifestations, coagulation parameters, pathogenesis, risk factors and their influence on treatment efficacy in patients receiving CAR-T-cell infusion. Due to limited data, these conclusions may undergo changes as more experience accumulates.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Blood Coagulation Disorders
/
Immunotherapy, Adoptive
/
Hematologic Neoplasms
Limits:
Humans
Language:
En
Journal:
Br J Haematol
Year:
2024
Type:
Article
Affiliation country:
China