Association of XRCC1 p. Arg194Trp gene polymorphism with the risk of hepatocellular carcinoma in HCV Egyptian population: A pilot case-control study.
Int J Immunopathol Pharmacol
; 38: 3946320241265263, 2024.
Article
in En
| MEDLINE
| ID: mdl-38898405
ABSTRACT
Background:
Hepatocellular carcinoma (HCC) is the most common and fatal primary liver cancer. Genetic variants of DNA repair systems can reduce DNA repair capability and increase HCC risk.Objectives:
This study aimed to examine, in Egyptian hepatitis C virus (HCV) patients, the relationship between the X-ray repair cross-complementing group 1 (XRCC1) rs1799782 single nucleotide polymorphism (SNP) and HCC susceptibility.Methods:
We included 100 adult HCV-positive patients with HCC and 100 adult HCV-positive patients with liver cirrhosis as pathological controls. XRCC1 rs1799782 SNP genotyping was done in both groups using quantitative real-time PCR (qPCR). The distribution of genotypes in patients and controls was compared using several inheritance models.Results:
We found that the CT genotype, when analyzed under both the co-dominant (OR (95 % CI) 2.147 (1.184-3.893), p = .012) and the over-dominant (OR (95 % CI) 2.055 (1.153-3.660), p = .015) models, as well as the combined CT and TT genotypes under the dominant model (OR (95 % CI) of 1.991 (1.133-3.497), p = .017), were associated with increased susceptibility to HCC. The frequency of the T allele was higher among HCC participants (32%) compared to those with cirrhosis (23.5%) and carrying the T allele increased the risk of HCC by 1.532 times, however, these associations did not reach statistical significance (p-values >0.05). Moreover, the variant T allele was associated with worse clinical manifestations and laboratory results among the HCC group, but AFP levels were not affected significantly.Conclusions:
Egyptians with XRCC1 rs1799782 SNP may have a higher risk of HCV-related HCC. More extensive multi-center prospective investigations must confirm this association.Key words
Full text:
1
Database:
MEDLINE
Main subject:
Carcinoma, Hepatocellular
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Genetic Predisposition to Disease
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Polymorphism, Single Nucleotide
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X-ray Repair Cross Complementing Protein 1
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Liver Neoplasms
Limits:
Adult
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Female
/
Humans
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Male
/
Middle aged
Country/Region as subject:
Africa
Language:
En
Journal:
Int J Immunopathol Pharmacol
Journal subject:
ALERGIA E IMUNOLOGIA
/
FARMACOLOGIA
/
PATOLOGIA
Year:
2024
Type:
Article
Affiliation country:
Egypt