Out of the dark: the emerging roles of lncRNAs in pain.
Trends Genet
; 40(8): 694-705, 2024 Aug.
Article
in En
| MEDLINE
| ID: mdl-38926010
ABSTRACT
The dark genome, the nonprotein-coding part of the genome, is replete with long noncoding RNAs (lncRNAs). These functionally versatile transcripts, with specific temporal and spatial expression patterns, are critical gene regulators that play essential roles in health and disease. In recent years, FAAH-OUT was identified as the first lncRNA associated with an inherited human pain insensitivity disorder. Several other lncRNAs have also been studied for their contribution to chronic pain and genome-wide association studies are frequently identifying single nucleotide polymorphisms that map to lncRNAs. For a long time overlooked, lncRNAs are coming out of the dark and into the light as major players in human pain pathways and as potential targets for new RNA-based analgesic medicines.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Pain
/
RNA, Long Noncoding
Limits:
Animals
/
Humans
Language:
En
Journal:
Trends Genet
/
Trends genet
/
Trends in genetics
Journal subject:
GENETICA
Year:
2024
Type:
Article
Affiliation country:
Qatar