Plasma amyloid beta X-42/X-40 ratio and cognitive decline in suspected early and preclinical Alzheimer's disease.
Alzheimers Dement
; 20(8): 5132-5142, 2024 08.
Article
in En
| MEDLINE
| ID: mdl-38940303
ABSTRACT
INTRODUCTION:
Blood-based biomarkers are a cost-effective and minimally invasive method for diagnosing the early and preclinical stages of amyloid positivity (AP). Our study aims to investigate our novel immunoprecipitation-immunoassay (IP-IA) as a test for predicting cognitive decline.METHODS:
We measured levels of amyloid beta (Aß)X-40 and AßX-42 in immunoprecipitated eluates from the DELCODE cohort. Receiver-operating characteristic (ROC) curves, regression analyses, and Cox proportional hazard regression models were constructed to predict AP by Aß42/40 classification in cerebrospinal fluid (CSF) and conversion to mild cognitive impairment (MCI) or dementia.RESULTS:
We detected a significant correlation between AßX-42/X-40 in plasma and CSF (r = 0.473). Mixed-modeling analysis revealed a substantial prediction of AßX-42/X-40 with an area under the curve (AUC) of 0.81 for AP (sensitivity 0.79, specificity 0.74, positive predictive value [PPV] 0.71, negative predictive value [NPV] 0.81). In addition, lower AßX-42/X-40 ratios were associated with negative PACC5 slopes, suggesting cognitive decline.DISCUSSION:
Our results suggest that assessing the plasma AßX-42/X-40 ratio via our semiautomated IP-IA is a promising biomarker when examining patients with early or preclinical AD. HIGHLIGHTS New plasma Aß42/Aß40 measurement using immunoprecipitation-immunoassay Plasma Aß42/Aß40 associated with longitudinal cognitive decline Promising biomarker to detect subjective cognitive decline at-risk for brain amyloid positivity.Key words
Full text:
1
Database:
MEDLINE
Main subject:
Peptide Fragments
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Biomarkers
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Amyloid beta-Peptides
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Alzheimer Disease
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Cognitive Dysfunction
Limits:
Aged
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Female
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Humans
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Male
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Middle aged
Language:
En
Journal:
Alzheimers Dement
Year:
2024
Type:
Article
Affiliation country:
United States