Plasma metabolites in childhood Burkitt lymphoma cases and cancer-free controls in Uganda.
Metabolomics
; 20(4): 67, 2024 Jun 28.
Article
in En
| MEDLINE
| ID: mdl-38940866
ABSTRACT
INTRODUCTION:
Burkitt lymphoma (BL) is an aggressive non-Hodgkin lymphoma associated with Plasmodium falciparum and Epstein-Barr virus, both of which affect metabolic pathways. The metabolomic patterns of BL is unknown. MATERIALS ANDMETHODS:
We measured 627 metabolites in pre-chemotherapy treatment plasma samples from 25 male children (6-11 years) with BL and 25 cancer-free area- and age-frequency-matched male controls from the Epidemiology of Burkitt Lymphoma in East African Children and Minors study in Uganda using liquid chromatography-tandem mass spectrometry. Unconditional, age-adjusted logistic regression analysis was used to estimate odds ratios (ORs) and their 95% confidence intervals (CIs) for the BL association with 1-standard deviation increase in the log-metabolite concentration, adjusting for multiple comparisons using false discovery rate (FDR) thresholds and Bonferroni correction.RESULTS:
Compared to controls, levels for 42 metabolite concentrations differed in BL cases (FDR < 0.001), including triacylglyceride (180_386), alpha-aminobutyric acid (AABA), ceramide (d181/200), phosphatidylcholine ae C406 and phosphatidylcholine C386 as the top signals associated with BL (ORs = 6.9 to 14.7, P < 2.4â10- 4). Two metabolites (triacylglyceride (180_386) and AABA) selected using stepwise logistic regression discriminated BL cases from controls with an area under the curve of 0.97 (95% CI 0.94, 1.00).CONCLUSION:
Our findings warrant further examination of plasma metabolites as potential biomarkers for BL risk/diagnosis.Key words
Full text:
1
Database:
MEDLINE
Main subject:
Burkitt Lymphoma
/
Metabolomics
Limits:
Child
/
Female
/
Humans
/
Male
Country/Region as subject:
Africa
Language:
En
Journal:
Metabolomics
Year:
2024
Type:
Article
Affiliation country:
China