ß-Mangostin targets and suppresses glioma via STING activation and tumor-associated microglia polarization.
Biomed Pharmacother
; 177: 117074, 2024 Aug.
Article
in En
| MEDLINE
| ID: mdl-38972149
ABSTRACT
Glioma, a common and highly malignant central nervous system tumor, markedly influences patient prognosis via interactions with glioma-associated macrophages. Previous research has revealed the anticancer potential of ß-mangostin, a xanthone derivative obtained from the mangosteen fruit. This research investigated the role of ß-mangostin on microglia in the glioma microenvironment and evaluated the efficacy of ß-mangostin combined with anti-PD-1 antibody (αPD-1) in glioma-bearing mice. The results showed that, ß-mangostin attenuated M2 polarization in BV2 cells and promoted M1-related interleukin (IL)-1ß and IL-6 secretion, thereby inhibiting glioma invasion. In addition, ß-mangostin improved the anti-glioma effects of αPD-1 and increased CD8+T cell and M1-type microglia infiltration. Mechanistically, ß-mangostin bound to the stimulator of interferon genes (STING) protein, which is crucial for the anti-tumor innate immune response, and promoted STING phosphorylation in microglia, both in vivo and in vitro. These results provide insights into its mode of action and supporting further investigation into ß-mangostin as a therapeutic agent.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Microglia
/
Xanthones
/
Glioma
/
Membrane Proteins
Limits:
Animals
/
Humans
/
Male
Language:
En
Journal:
Biomed Pharmacother
Year:
2024
Type:
Article