Differential inducibility of transmembrane peptidoglycan recognition proteins (PGRPs) by bacterial challenges in the earthworm, Eisenia andrei.
J Invertebr Pathol
; 206: 108166, 2024 Sep.
Article
in En
| MEDLINE
| ID: mdl-39004164
ABSTRACT
Peptidoglycan recognition proteins (PGRPs) and Toll-like receptors (TLRs) are highly conserved pattern recognition receptors (PRRs). Earthworms possess genes encoding TLRs that specifically respond to Gram-positive bacteria. In addition, several PGRPs have been recently identified, which are predicted to exhibit amidase activity but lack receptor function. In lophotrochozoans, a membrane-bound PRR responsible for detecting Gram-negative bacteria remains unidentified. This study reveals several novel transmembrane peptidoglycan recognition proteins (Ean-PGRPLs) in earthworms, whose mRNA expression increases in response to Gram-negative but not Gram-positive bacteria. This indicates that Ean-PGRPLs may serve as a PRR associated with intracellular signaling for Gram-negative bacteria.
Full text:
1
Database:
MEDLINE
Main subject:
Oligochaeta
/
Carrier Proteins
Limits:
Animals
Language:
En
Journal:
J Invertebr Pathol
Year:
2024
Type:
Article