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[18F]-florbetaben PET/CT is sensitive for cardiac AL amyloidosis.
Cassano Cassano, Raffaella; Genovesi, Dario; Vergaro, Giuseppe; Giorgetti, Assuero; Aimo, Alberto; Del Giudice, Maria Livia; Galimberti, Sara; Emdin, Michele; Buda, Gabriele.
Affiliation
  • Cassano Cassano R; Hematology Unit, Department of Clinical And Experimental Medicine, University of Pisa, Pisa, Italy.
  • Genovesi D; Division of Nuclear Medicine, Fondazione Toscana Gabriele Monasterio, Pisa, Italy.
  • Vergaro G; Division of Cardiology and Cardiovascular Medicine, Fondazione Toscana Gabriele Monasterio, Pisa, Italy.
  • Giorgetti A; Interdisciplinary Center for Health Sciences, Scuola Superiore Sant'Anna, Pisa, Italy.
  • Aimo A; Division of Nuclear Medicine, Fondazione Toscana Gabriele Monasterio, Pisa, Italy.
  • Del Giudice ML; Division of Cardiology and Cardiovascular Medicine, Fondazione Toscana Gabriele Monasterio, Pisa, Italy.
  • Galimberti S; Interdisciplinary Center for Health Sciences, Scuola Superiore Sant'Anna, Pisa, Italy.
  • Emdin M; Hematology Unit, Department of Clinical And Experimental Medicine, University of Pisa, Pisa, Italy.
  • Buda G; Hematology Unit, Department of Clinical And Experimental Medicine, University of Pisa, Pisa, Italy.
Eur J Clin Invest ; : e14270, 2024 Jul 17.
Article in En | MEDLINE | ID: mdl-39021058
ABSTRACT
Often differential diagnosis between AL and ATTR amyloidosis is difficult. Concerning ATTR, sensitive diagnostic tool, as diphosphonate scintigraphy, was validated, instead of no imaging approach is as accurate in AL. Cardiac ultrasound and circulating biomarkers may raise the clinical suspicion but biopsy remains the only option for diagnosis. We aimed to explore the sensitivity of 18F-Florbetaben PET respect to blood tests or periumbilical fat (POF), cardiac, bone marrow (BM) or other tissues biopsies in a cohort of 33 patients.
Key words

Full text: 1 Database: MEDLINE Language: En Journal: Eur J Clin Invest Year: 2024 Type: Article Affiliation country: Italy

Full text: 1 Database: MEDLINE Language: En Journal: Eur J Clin Invest Year: 2024 Type: Article Affiliation country: Italy