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New recognition of the heart-brain axis and its implication in the pathogenesis and treatment of PTSD.
Li, Hai-Peng; Cheng, Hong-Liang; Ding, Keke; Zhang, Yang; Gao, Fang; Zhu, Guoqi; Zhang, Zhengrong.
Affiliation
  • Li HP; Anhui University of Chinese Medicine, Hefei, China.
  • Cheng HL; The Affiliated Hospital of Acupuncture and Moxibustion, Anhui University of Chinese Medicine, Hefei, Anhui Province, China.
  • Ding K; Anhui University of Chinese Medicine, Hefei, China.
  • Zhang Y; Anhui University of Chinese Medicine, Hefei, China.
  • Gao F; Anhui University of Chinese Medicine, Hefei, China.
  • Zhu G; Anhui University of Chinese Medicine, Hefei, China.
  • Zhang Z; Anhui University of Chinese Medicine, Hefei, China.
Eur J Neurosci ; 60(4): 4661-4683, 2024 Aug.
Article in En | MEDLINE | ID: mdl-39044332
ABSTRACT
Post-traumatic stress disorder (PTSD) is a complex psychological disorder provoked by distressing experiences, and it remains without highly effective intervention strategies. The exploration of PTSD's underlying mechanisms is crucial for advancing diagnostic and therapeutic approaches. Current studies primarily explore PTSD through the lens of the central nervous system, investigating concrete molecular alterations in the cerebral area and neural circuit irregularities. However, the body's response to external stressors, particularly the changes in cardiovascular function, is often pronounced, evidenced by notable cardiac dysfunction. Consequently, examining PTSD with a focus on cardiac function is vital for the early prevention and targeted management of the disorder. This review undertakes a comprehensive literature analysis to detail the alterations in brain and heart structures and functions associated with PTSD. It also synthesizes potential mechanisms of heart-brain axis interactions relevant to the development of PTSD. Ultimately, by considering cardiac function, this review proposes novel perspectives for PTSD's prophylaxis and therapy.
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Full text: 1 Database: MEDLINE Main subject: Stress Disorders, Post-Traumatic / Brain / Heart Limits: Animals / Humans Language: En Journal: Eur J Neurosci Journal subject: NEUROLOGIA Year: 2024 Type: Article Affiliation country: China

Full text: 1 Database: MEDLINE Main subject: Stress Disorders, Post-Traumatic / Brain / Heart Limits: Animals / Humans Language: En Journal: Eur J Neurosci Journal subject: NEUROLOGIA Year: 2024 Type: Article Affiliation country: China