The Impact of Tobacco Smoking and Alcohol Consumption on the Development of Gastric Cancers.
Int J Mol Sci
; 25(14)2024 Jul 18.
Article
in En
| MEDLINE
| ID: mdl-39063094
ABSTRACT
Chronic infection of Helicobacter pylori is considered the principal cause of gastric cancers, but evidence has accumulated regarding the impact of tobacco smoking and alcohol consumption on the development of gastric cancers. Several possible mechanisms, including the activation of nicotinic acetylcholine receptors, have been proposed for smoking-induced gastric carcinogenesis. On the other hand, local acetaldehyde exposure and ethanol-induced mucosal inflammation have been proposed as the mechanisms involved in the development of gastric cancers in heavy alcohol drinkers. In addition, genetic polymorphisms are also considered to play a pivotal role in smoking-related and alcohol-related gastric carcinogenesis. In this review, we will discuss the molecular mechanisms involved in the development of gastric cancers in relation to tobacco smoking and alcohol consumption.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Stomach Neoplasms
/
Alcohol Drinking
/
Tobacco Smoking
Limits:
Animals
/
Humans
Language:
En
Journal:
Int J Mol Sci
Year:
2024
Type:
Article
Affiliation country:
Japan