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Phase 1 Trials of PNPLA3 siRNA in I148M Homozygous Patients with MAFLD.
Fabbrini, Elisa; Rady, Brian; Koshkina, Anastasiya; Jeon, Jae Yoon; Ayyar, Vivaswath S; Gargano, Cynthia; DiProspero, Nicholas; Wendel, Susan; Hegge, Julia; Hamilton, Holly; Ding, Zhi-Ming; Afrazi, Maria; Nicholas, Anthony; Pei, Tao; Nakano, Masayoshi; Ouchi, Shohei; Saito, Yuki; Yamashita, Aimi; Tamamura, Ryo; Salazar, Hernan; Shapiro, Craig; Yoshihara, Tatsuya; Yonemura, Takuma; Inoue, Satoshi; Matsuoka, Osamu; Erion, Mark; Pocai, Alessandro; Makimura, Hideo.
Affiliation
  • Fabbrini E; Janssen Research and Development, Raritan, NJ elifabbrini@gmail.com.
  • Rady B; Janssen Research and Development, Spring House, PA.
  • Koshkina A; Janssen Research and Development, Raritan, NJ.
  • Jeon JY; Janssen Research and Development, Raritan, NJ.
  • Ayyar VS; Janssen Research and Development, Spring House, PA.
  • Gargano C; Janssen Research and Development, Spring House, PA.
  • DiProspero N; Janssen Research and Development, Raritan, NJ.
  • Wendel S; Janssen Research and Development, Raritan, NJ.
  • Hegge J; Arrowhead Pharmaceuticals, Pasadena, CA.
  • Hamilton H; Arrowhead Pharmaceuticals, Pasadena, CA.
  • Ding ZM; Arrowhead Pharmaceuticals, Pasadena, CA.
  • Afrazi M; Arrowhead Pharmaceuticals, Pasadena, CA.
  • Nicholas A; Arrowhead Pharmaceuticals, Pasadena, CA.
  • Pei T; Arrowhead Pharmaceuticals, Pasadena, CA.
  • Nakano M; Janssen Pharmaceutical, Tokyo, Japan.
  • Ouchi S; Janssen Pharmaceutical, Tokyo, Japan.
  • Saito Y; Janssen Pharmaceutical, Tokyo, Japan.
  • Yamashita A; Janssen Pharmaceutical, Tokyo, Japan.
  • Tamamura R; Janssen Pharmaceutical, Tokyo, Japan.
  • Salazar H; Endeavor Clinical Trials, San Antonio, TX.
  • Shapiro C; CenExel RCA, Hollywood, FL.
  • Yoshihara T; Souseikai Fukuoka Mirai Hospital, Fukuoka, Japan.
  • Yonemura T; Sumida Hospital, Tokyo, Japan.
  • Inoue S; OCROM Clinic, Osaka, Japan.
  • Matsuoka O; Medical Corporation Heishinkai, Tokyo, Japan.
  • Erion M; Janssen Research and Development, Spring House, PA.
  • Pocai A; Janssen Research and Development, Spring House, PA.
  • Makimura H; Janssen Research and Development, Raritan, NJ.
N Engl J Med ; 391(5): 475-476, 2024 Aug 01.
Article in En | MEDLINE | ID: mdl-39083780
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Full text: 1 Database: MEDLINE Main subject: RNA, Small Interfering / Homozygote / Lipase / Membrane Proteins Limits: Adolescent / Adult / Child / Female / Humans / Male Language: En Journal: N Engl J Med Year: 2024 Type: Article
Fulltext
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Full text: 1 Database: MEDLINE Main subject: RNA, Small Interfering / Homozygote / Lipase / Membrane Proteins Limits: Adolescent / Adult / Child / Female / Humans / Male Language: En Journal: N Engl J Med Year: 2024 Type: Article