Asymmetric Total Synthesis of Euphordraculoate A and Pedrolide.
Angew Chem Int Ed Engl
; : e202409997, 2024 Jul 31.
Article
in En
| MEDLINE
| ID: mdl-39085985
ABSTRACT
Here we report the asymmetric total syntheses of two rearranged tigliane diterpenoids, euphordraculoate A and pedrolide. A reductive dihydroxylation cascade and Nazarov cyclization were performed to generate euphordraculoate A, which was subjected to a cascade of Eu-promoted dienyl enolization, intramolecular Diels-Alder reaction and enol-ketone tautomerization to afford pedrolide, a pathway consistent with our proposal for the biogenesis of pedrolide.
Full text:
1
Database:
MEDLINE
Language:
En
Journal:
Angew Chem Int Ed Engl
Year:
2024
Type:
Article
Affiliation country:
China