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Dissociating the metabolic and tumor-suppressive activity of p53.
Sakurai, Yoshitaka; Kubota, Naoto; Kadowaki, Takashi.
Affiliation
  • Sakurai Y; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Kubota N; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan; Department of Metabolic Medicine, Faculty of Life Science, Kumamoto University, Kumamoto, Japan.
  • Kadowaki T; Toranomon Hospital, Tokyo, Japan. Electronic address: t-kadowaki@toranomon.kkr.or.jp.
Trends Endocrinol Metab ; 2024 Aug 01.
Article in En | MEDLINE | ID: mdl-39095229
ABSTRACT
The tumor suppressor p53 regulates metabolic homeostasis. Recently, Tsaousidou et al. reported that selective activation of p53 via downregulation of Tudor interacting repair regulator (TIRR) confers protection against cancer despite obesity and insulin resistance, providing new insights into the role of p53 at the intersection of oncogenesis and systemic metabolism.
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Full text: 1 Database: MEDLINE Language: En Journal: Trends Endocrinol Metab Journal subject: ENDOCRINOLOGIA / METABOLISMO Year: 2024 Type: Article Affiliation country: Japan
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Full text: 1 Database: MEDLINE Language: En Journal: Trends Endocrinol Metab Journal subject: ENDOCRINOLOGIA / METABOLISMO Year: 2024 Type: Article Affiliation country: Japan