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Longitudinal associations of DXA-measured visceral adipose tissue and cardiometabolic risk in middle-to-older aged adults.
Zhu, Kun; Walsh, John P; Hunter, Michael; Murray, Kevin; Hui, Jennie; Hung, Joseph.
Affiliation
  • Zhu K; Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Perth, Australia; Medical School, University of Western Australia, Perth, Australia. Electronic address: kun.zhu@uwa.edu.au.
  • Walsh JP; Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Perth, Australia; Medical School, University of Western Australia, Perth, Australia.
  • Hunter M; School of Population and Global Health, University of Western Australia, Perth, Australia; Busselton Population Medical Research Institute, Busselton, Australia.
  • Murray K; School of Population and Global Health, University of Western Australia, Perth, Australia.
  • Hui J; School of Population and Global Health, University of Western Australia, Perth, Australia; Busselton Population Medical Research Institute, Busselton, Australia; Department of Diagnostic Genomics, PathWest Laboratory Medicine, Queen Elizabeth II Medical Centre, Perth, Australia.
  • Hung J; Medical School, University of Western Australia, Perth, Australia.
Article in En | MEDLINE | ID: mdl-39098379
ABSTRACT
BACKGROUND AND

AIMS:

DXA-measured visceral adipose tissue (VATDXA) is associated with adverse cardiometabolic risk profiles in cross-sectional studies, but longitudinal associations have not been investigated. We examined the longitudinal associations of baseline and change in VATDXA with future cardiometabolic risk in Australian participants of the Busselton Healthy Ageing study. METHODS AND

RESULTS:

We studied 3569 participants (54.7% female, aged 46-70 years) with data on VATDXA (GE Lunar Prodigy) and cardiometabolic risk factors at baseline and 6 years follow-up. The associations were examined using logistic and linear regression models, adjusting for baseline age and lifestyle factors. Mean baseline VATDXA mass was 1653 ± 880 g and 855 ± 580 g, and mean change in VATDXA +99 ± 500 g and +58 ± 312 g in males and females, respectively. Among all participants, 182 males (11.3%) and 197 females (10.1%) developed incident metabolic syndrome (MetS). Baseline VATDXA was associated with incident MetS with an adjusted odds ratio of 2.53 (95% CI 2.03, 3.15) in males and 2.78 (2.30, 3.36) in females per SD increment. There was a graded positive association between longitudinal change in VATDXA and MetS severity z score in both sexes adjusted for baseline VAT (P < 0.001). All the above associations remained significant after further adjustment for baseline or change in BMI, waist circumference or waist-to-hip ratio in respective models (all P < 0.001).

CONCLUSIONS:

Higher baseline and greater longitudinal increase in VATDXA are independently associated with raised cardiometabolic risk over time, and may serve as useful markers for identifying middle-aged individuals at increased cardiometabolic risk.
Key words

Full text: 1 Database: MEDLINE Language: En Journal: Nutr Metab Cardiovasc Dis Journal subject: ANGIOLOGIA / CARDIOLOGIA / CIENCIAS DA NUTRICAO / METABOLISMO Year: 2024 Type: Article

Full text: 1 Database: MEDLINE Language: En Journal: Nutr Metab Cardiovasc Dis Journal subject: ANGIOLOGIA / CARDIOLOGIA / CIENCIAS DA NUTRICAO / METABOLISMO Year: 2024 Type: Article