Multi-omics analysis reveals genes and metabolites involved in Streptococcus suis biofilm formation.
BMC Microbiol
; 24(1): 297, 2024 Aug 10.
Article
in En
| MEDLINE
| ID: mdl-39127666
ABSTRACT
BACKGROUND:
Streptococcus suis is an important zoonotic pathogen. Biofilm formation largely explains the difficulty in preventing and controlling S. suis. However, little is known about the molecular mechanism of S. suis biofilm formation.RESULTS:
In this study, transcriptomic and metabolomic analyses of S. suis in biofilm and planktonic states were performed to identify key genes and metabolites involved in biofilm formation. A total of 789 differential genes and 365 differential metabolites were identified. By integrating transcriptomics and metabolomics, five main metabolic pathways were identified, including amino acid pathway, nucleotide metabolism pathway, carbon metabolism pathway, vitamin and cofactor metabolism pathway, and aminoacyl-tRNA biosynthesis metabolic pathway.CONCLUSIONS:
These results provide new insights for exploring the molecular mechanism of S. suis biofilm formation.Key words
Full text:
1
Database:
MEDLINE
Main subject:
Streptococcus suis
/
Biofilms
/
Metabolomics
Language:
En
Journal:
BMC Microbiol
Journal subject:
MICROBIOLOGIA
Year:
2024
Type:
Article
Affiliation country:
China