Genetic Features of Tongue Cancer Recurrence in Young Adults.
Bull Exp Biol Med
; 177(3): 359-362, 2024 Jul.
Article
in En
| MEDLINE
| ID: mdl-39127975
ABSTRACT
To identify genetic alterations associated with tongue cancer recurrence in young adults, whole exome sequencing of the primary tumor, recurrence, and whole blood samples from young patients with tongue cancer was performed. A frameshift mutation in the TP53 gene was detected in the primary tumor and recurrence tumor tissue. A mutation in the EPHB6 gene was detected in the recurrence and was absent in the primary tumor. In addition, the primary tumor and recurrence tongue cancer tissue harbored amplification of the 20p13 region containing C20orf96, DEFB125, DEFB126, DEFB127, DEFB128, DEFB129, DEFB132, and ZCCHC3 genes. Thus, genetic alterations have been identified that are associated with tongue cancer recurrence in young adults.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Tongue Neoplasms
/
Tumor Suppressor Protein p53
/
Exome Sequencing
/
Neoplasm Recurrence, Local
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
En
Journal:
Bull Exp Biol Med
Year:
2024
Type:
Article
Affiliation country:
RUSSIA