Light and electron microscopic studies of diet-induced hepatic changes in mice.
Acta Anat (Basel)
; 125(3): 174-9, 1986.
Article
in En
| MEDLINE
| ID: mdl-3962578
ABSTRACT
Adult mice were fed a choline-deficient ethionine enriched (CDE) diet for 24, 48 or 72 h. They were then fasted for 24 or 48 h prior to sacrifice. All tissues were studied by light and electron microscopy. Animals fed the CDE diet for 24 h exhibited cells with vacuolated cytoplasm, and the accumulation of lipid in these cells was clearly abnormal. Animals fed the CDE diet for 24 h and subsequently a regular diet for 48 h displayed normal hepatocytes, suggesting that the alterations at 24 h were reversible. Following 48 or 72 h of feeding the CDE diet, abundant lipid-laden cells were observed in the hepatic lobules, and at the electron microscope level these cells were undergoing frank degeneration. Evidence indicated that changes after 48 or 72 h were irreversible.
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Database:
MEDLINE
Main subject:
Choline Deficiency
/
Ethionine
/
Liver
Limits:
Animals
Language:
En
Journal:
Acta Anat (Basel)
Year:
1986
Type:
Article