Suppressive effect of interferon on erythroid cell proliferation.
Exp Hematol
; 7(3): 145-50, 1979 Mar.
Article
in En
| MEDLINE
| ID: mdl-446582
ABSTRACT
The effect of interferon on mouse and human in vitro erythropoiesis was investigated using the mouse marrow CFU-E and the human blood BFU-E systems, respectively. Homologous interferons were found to have a marked inhibitory effect on mouse CFU-E and human BFU-E proliferation. This inhibitory effect was dose related and independent of the erythropoietin concentration used. The effective concentration of human interferon was within the range observed in humans following viral infections. It is suggested that interferon may play a role in the mechanism of the acute erythroblastopenic crisis observed at times in patients with chronic anemia following viral infections.
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Database:
MEDLINE
Main subject:
Interferons
/
Erythropoiesis
Limits:
Adult
/
Animals
/
Humans
/
Male
Language:
En
Journal:
Exp Hematol
Year:
1979
Type:
Article