The enzymatic synthesis of 5-amino-4-imidazolecarboxamide riboside triphosphate (ZTP).
Science
; 223(4641): 1193-5, 1984 Mar 16.
Article
in En
| MEDLINE
| ID: mdl-6199843
ABSTRACT
5-Amino-4-imidazolecarboxamide riboside triphosphate (ZTP) is thought to play a regulatory role in cellular metabolism. Unlike other nucleoside triphosphates, ZTP is synthesized in a one-step reaction in which the pyrophosphate group of 5-phosphoribosyl-l-pyrophosphate is transferred to the riboside monophosphate (ZMP) in a reaction catalyzed by 5-phosphoribosyl-l-pyrophosphate synthetase; reversal of this reaction leads to dephosphorylation of ZTP to ZMP. This unusual route of synthesis (and catabolism) of ZTP may be important in defining its metabolic effects in the cell.
Search on Google
Database:
MEDLINE
Main subject:
Ribonucleotides
/
Aminoimidazole Carboxamide
/
Imidazoles
Limits:
Animals
Language:
En
Journal:
Science
Year:
1984
Type:
Article