Induction of resistance to 2',2'-difluorodeoxycytidine in the human ovarian cancer cell line A2780.

Ruiz van Haperen, V W; Veerman, G; Eriksson, S; Stegmann, A P; Peters, G J

Ruiz van Haperen, V W; Veerman, G; Eriksson, S; Stegmann, A P; Peters, G J.

Affiliation

Ruiz van Haperen VW; Department of Oncology, Free University Hospital, Amsterdam, The Netherlands.

Semin Oncol ; 22(4 Suppl 11): 35-41, 1995 Aug.

Article in En | MEDLINE | ID: mdl-7481843

Subject(s)

Antimetabolites, Antineoplastic/pharmacology; Deoxycytidine Kinase/drug effects; Deoxycytidine/analogs & derivatives; Ovarian Neoplasms/drug therapy; Ribonucleotide Reductases/antagonists & inhibitors; Tumor Cells, Cultured/drug effects; Antibiotics, Antineoplastic/pharmacology; Antineoplastic Agents, Phytogenic/pharmacology; Base Sequence; Cell Division/drug effects; Cytidine Deaminase; Deoxycytidine/pharmacology; Deoxycytidine Kinase/deficiency; Deoxycytidine Kinase/metabolism; Dose-Response Relationship, Drug; Doxorubicin/pharmacology; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Humans; Molecular Sequence Data; Nucleoside Deaminases/metabolism; Ovarian Neoplasms/enzymology; Ovarian Neoplasms/pathology; Phenotype; RNA, Messenger/analysis; Tumor Cells, Cultured/enzymology; Tumor Cells, Cultured/pathology; Vincristine/pharmacology; Gemcitabine

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Database: MEDLINE Main subject: Ovarian Neoplasms / Ribonucleotide Reductases / Tumor Cells, Cultured / Deoxycytidine / Deoxycytidine Kinase / Antimetabolites, Antineoplastic Limits: Female / Humans Language: En Journal: Semin Oncol Year: 1995 Type: Article Affiliation country: Netherlands

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