Human complement regulatory proteins protect swine-to-primate cardiac xenografts from humoral injury.
Nat Med
; 1(5): 423-7, 1995 May.
Article
in En
| MEDLINE
| ID: mdl-7585088
ABSTRACT
The susceptibility of xenografts to hyperacute rejection is postulated to reflect in part failure of complement regulatory proteins (CRPs) to control activation of heterologous complement on graft endothelium. To test this concept, transgenic swine expressing the human CRP decay accelerating factor and CD59 were developed using a novel expression system involving transfer of the proteins from erythrocytes to endothelial cells. Hearts from transgenic swine transplanted into baboons had markedly less vascular injury and functioned for prolonged periods compared to hearts from nontransgenic swine. These results indicate that expression of human CRPs in xenogeneic organs may contribute to successful xenografting and suggest that intercellular protein transfer might be a useful approach for expression of heterologous proteins in endothelial cells.
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Database:
MEDLINE
Main subject:
Transplantation, Heterologous
/
Complement System Proteins
/
Heart Transplantation
Limits:
Animals
/
Humans
Language:
En
Journal:
Nat Med
Journal subject:
BIOLOGIA MOLECULAR
/
MEDICINA
Year:
1995
Type:
Article
Affiliation country:
United States