Resistance to DL-alpha-difluoromethylornithine by clinical isolates of Trypanosoma brucei rhodesiense. Role of S-adenosylmethionine.

Bacchi, C J; Garofalo, J; Ciminelli, M; Rattendi, D; Goldberg, B; McCann, P P; Yarlett, N

Bacchi, C J; Garofalo, J; Ciminelli, M; Rattendi, D; Goldberg, B; McCann, P P; Yarlett, N.

Affiliation

Bacchi CJ; Haskins Laboratory, Pace University, New York, NY 10038-1502.

Biochem Pharmacol ; 46(3): 471-81, 1993 Aug 03.

Article in En | MEDLINE | ID: mdl-8347171

Subject(s)

Eflornithine/pharmacology; Trypanosoma brucei rhodesiense/drug effects; Animals; Drug Resistance, Microbial; Mice; Ornithine/metabolism; Polyamines/metabolism; Polyamines/pharmacology; S-Adenosylmethionine/metabolism; Trypanosoma brucei rhodesiense/isolation & purification; Trypanosoma brucei rhodesiense/metabolism; Trypanosomiasis/parasitology

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Database: MEDLINE Main subject: Eflornithine / Trypanosoma brucei rhodesiense Limits: Animals Language: En Journal: Biochem Pharmacol Year: 1993 Type: Article

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PubMed Links

Database: MEDLINE Main subject: Eflornithine / Trypanosoma brucei rhodesiense Limits: Animals Language: En Journal: Biochem Pharmacol Year: 1993 Type: Article