The synthetic phosphagen cyclocreatine phosphate inhibits the growth of a broad spectrum of solid tumors.
Anticancer Res
; 16(1): 375-80, 1996.
Article
in En
| MEDLINE
| ID: mdl-8615639
ABSTRACT
BACKGROUND:
The brain isoform of creatine kinase (CKBB), an enzyme involved in energy metabolism, has been implicated in cellular transformation process. Cyclocreatine (CCr), a creatine kinase (CK) substrate analogue, was shown to inhibit the growth of a broad spectrum of solid tumors expressing high levels of CK. Cyclocreatine phosphate (CCrP) generated by CK, was proposed to be the active form responsible for growth inhibition. MATERIALS ANDMETHODS:
We synthesized CCrP and tested its cellular uptake and anti tumor activity in stem cell assays and in athymic mouse models.RESULTS:
CCrP seems to be taken up by cells and inhibits the growth of solid tumors with high levels of CK. CCr and CCrP have similar specificity and potency.CONCLUSION:
The observation that only high-CK cell lines were responsive to CCrP, similar to CCr, indicates that the enzyme requirement was not bypassed. We propose that CK is a target for CCrP, and is involved in mediating its antiproliferative activity.
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Database:
MEDLINE
Main subject:
Phosphocreatine
/
Imidazolidines
/
Neoplasms
/
Antineoplastic Agents
Limits:
Animals
/
Female
/
Humans
/
Male
Language:
En
Journal:
Anticancer Res
Year:
1996
Type:
Article
Affiliation country:
United States