IgG antibody to pneumococcal capsular polysaccharide in human immunodeficiency virus-infected subjects: persistence of antibody in responders, revaccination in nonresponders, and relationship of immunoglobulin allotype to response.
J Infect Dis
; 173(6): 1347-53, 1996 Jun.
Article
in En
| MEDLINE
| ID: mdl-8648206
ABSTRACT
Human immunodeficiency virus (HIV)-infected persons are less likely than are noninfected persons to respond to vaccination with pneumococcal polysaccharides (PPS). Among those who respond, however, similar IgG levels may be achieved. HIV-infected men immunized with pneumococcal vaccine were classified as high- or low-level responders (IgG > or = 1 microgram/mL for > or = 3 of 5 PPS [high] or for < or = 1 PPS [low]). One and 2 years after immunization, geometric mean IgG levels and the percentages of subjects with IgG levels > or = 1 microgram/mL were similar for HIV-infected and for healthy high-level responders (controls) for all PPS except for serotype 8. Among HIV-infected low-level responders, revaccination with a double dose of pneumococcal vaccine did not stimulate IgG responses. Responsiveness of HIV-infected white patients was significantly associated with the Km(1)- negative allotype. These findings support current general recommended guidelines for administering pneumococcal vaccine to HIV-infected persons. Nonresponders will not benefit from revaccination.
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Database:
MEDLINE
Main subject:
Streptococcus pneumoniae
/
Immunoglobulin G
/
Bacterial Vaccines
/
HIV Infections
/
Immunoglobulin Allotypes
/
Antibodies, Bacterial
Limits:
Adult
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
J Infect Dis
Year:
1996
Type:
Article
Affiliation country:
United States