Kinetics of response in lymphoid tissues to antiretroviral therapy of HIV-1 infection.
Science
; 276(5314): 960-4, 1997 May 09.
Article
in En
| MEDLINE
| ID: mdl-9139661
ABSTRACT
In lymphoid tissue, where human immunodeficiency virus-type 1 (HIV-1) is produced and stored, three-drug treatment with viral protease and reverse transcriptase inhibitors markedly reduced viral burden. This was shown by in situ hybridization and computerized quantitative analysis of serial tonsil biopsies from previously untreated adults. The frequency of productive mononuclear cells (MNCs) initially diminished with a half-life of about 1 day. Surprisingly, the amount of HIV-1 RNA in virus trapped on follicular dendritic cells (FDCs) decreased almost as quickly. After 24 weeks, MNCs with very few copies of HIV-1 RNA per cell were still detectable, as was proviral DNA; however, the amount of FDC-associated virus decreased by >/=3.4 log units. Thus, 6 months of potent therapy controlled active replication and cleared >99.9 percent of virus from the secondary lymphoid tissue reservoir.
Search on Google
Database:
MEDLINE
Main subject:
Palatine Tonsil
/
Dendritic Cells
/
Leukocytes, Mononuclear
/
HIV Infections
/
HIV-1
/
Anti-HIV Agents
Type of study:
Clinical_trials
Limits:
Adult
/
Humans
Language:
En
Journal:
Science
Year:
1997
Type:
Article
Affiliation country:
United States