Evaluation of omeprazole and lansoprazole as inhibitors of cytochrome P450 isoforms.

Ko, J W; Sukhova, N; Thacker, D; Chen, P; Flockhart, D A

Ko, J W; Sukhova, N; Thacker, D; Chen, P; Flockhart, D A.

Affiliation

Ko JW; Department of Medicine, Georgetown University Medical Center, Washington, DC 20007, USA.

Drug Metab Dispos ; 25(7): 853-62, 1997 Jul.

Article in En | MEDLINE | ID: mdl-9224780

Subject(s)

Cytochrome P-450 Enzyme Inhibitors; Enzyme Inhibitors/pharmacology; Isoenzymes/antagonists & inhibitors; Omeprazole/analogs & derivatives; Omeprazole/pharmacology; 2-Pyridinylmethylsulfinylbenzimidazoles; Chlorzoxazone/metabolism; Dextromethorphan/metabolism; Humans; In Vitro Techniques; Lansoprazole; Mephenytoin/metabolism; Microsomes, Liver/enzymology; Phenacetin/metabolism; Tolbutamide/metabolism

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Database: MEDLINE Main subject: Omeprazole / Enzyme Inhibitors / Cytochrome P-450 Enzyme Inhibitors / Isoenzymes Limits: Humans Language: En Journal: Drug Metab Dispos Journal subject: FARMACOLOGIA Year: 1997 Type: Article Affiliation country: United States

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