Co-expression of the herpes simplex virus thymidine kinase gene potentiates methotrexate resistance conferred by transfer of a mutated dihydrofolate reductase gene.

Mineishi, S; Nakahara, S; Takebe, N; Banerjee, D; Zhao, S C; Bertino, J R

Mineishi, S; Nakahara, S; Takebe, N; Banerjee, D; Zhao, S C; Bertino, J R.

Affiliation

Mineishi S; Program of Molecular Pharmacology and Experimental Therapeutics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.

Gene Ther ; 4(6): 570-6, 1997 Jun.

Article in En | MEDLINE | ID: mdl-9231073

Subject(s)

Antimetabolites, Antineoplastic; Gene Transfer Techniques; Genetic Therapy/methods; Methotrexate; Simplexvirus/enzymology; Tetrahydrofolate Dehydrogenase/genetics; Thymidine Kinase/genetics; 3T3 Cells; Animals; Antiviral Agents/therapeutic use; Bone Marrow Cells; Coculture Techniques; Drug Resistance, Neoplasm; Ganciclovir/therapeutic use; Gene Expression; Genetic Vectors; Male; Mice; Mice, Inbred C57BL; Mutation; Retroviridae

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Database: MEDLINE Main subject: Tetrahydrofolate Dehydrogenase / Thymidine Kinase / Genetic Therapy / Methotrexate / Simplexvirus / Gene Transfer Techniques / Antimetabolites, Antineoplastic Limits: Animals Language: En Journal: Gene Ther Journal subject: GENETICA MEDICA / TERAPEUTICA Year: 1997 Type: Article Affiliation country: United States

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