Methylation of discrete regions of the O6-methylguanine DNA methyltransferase (MGMT) CpG island is associated with heterochromatinization of the MGMT transcription start site and silencing of the gene.

Watts, G S; Pieper, R O; Costello, J F; Peng, Y M; Dalton, W S; Futscher, B W

Watts, G S; Pieper, R O; Costello, J F; Peng, Y M; Dalton, W S; Futscher, B W.

Affiliation

Watts GS; Bone Marrow Transplant Program, Arizona Cancer Center, and Department of Pharmacology, University of Arizona, Tucson 85724, USA.

Mol Cell Biol ; 17(9): 5612-9, 1997 Sep.

Article in En | MEDLINE | ID: mdl-9271436

Subject(s)

Chromatin/metabolism; CpG Islands; DNA Methylation; Methyltransferases/metabolism; Transcription, Genetic; Calcium Channel Blockers/pharmacology; Cells, Cultured; Cytosine/metabolism; DNA Repair/drug effects; Gene Expression/drug effects; Humans; Methyltransferases/genetics; O(6)-Methylguanine-DNA Methyltransferase; Restriction Mapping; Verapamil/pharmacology

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Full text: 1 Database: MEDLINE Main subject: Transcription, Genetic / Chromatin / CpG Islands / DNA Methylation / Methyltransferases Type of study: Risk_factors_studies Limits: Humans Language: En Journal: Mol Cell Biol Year: 1997 Type: Article Affiliation country: United States

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