Adrenaline stimulates glucagon secretion in pancreatic A-cells by increasing the Ca2+ current and the number of granules close to the L-type Ca2+ channels.

Gromada, J; Bokvist, K; Ding, W G; Barg, S; Buschard, K; Renström, E; Rorsman, P

Gromada, J; Bokvist, K; Ding, W G; Barg, S; Buschard, K; Renström, E; Rorsman, P.

Affiliation

Gromada J; Department of Islet Cell Physiology, Novo Nordisk A/S, The Symbion Science Park, DK-2100 Copenhagen. JLG@novo.dk

J Gen Physiol ; 110(3): 217-28, 1997 Sep.

Article in En | MEDLINE | ID: mdl-9276750

Subject(s)

Calcium Channels/metabolism; Calcium/physiology; Epinephrine/pharmacology; Glucagon/metabolism; Islets of Langerhans/metabolism; Islets of Langerhans/physiology; Animals; Cyclic AMP/pharmacology; Cyclic AMP-Dependent Protein Kinases/metabolism; Cytoplasm/metabolism; Electric Conductivity; Enzyme Activation; Exocytosis/drug effects; Exocytosis/physiology; Glucose/metabolism; Islets of Langerhans/drug effects; Male; Osmolar Concentration; Rats; Rats, Inbred Lew; Receptors, Adrenergic, beta/physiology

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Full text: 1 Database: MEDLINE Main subject: Glucagon / Calcium Channels / Epinephrine / Calcium / Islets of Langerhans Limits: Animals Language: En Journal: J Gen Physiol Year: 1997 Type: Article

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