Inhibition of poly (ADP-ribose) synthetase attenuates neutrophil recruitment and exerts antiinflammatory effects.

Szabó, C; Lim, L H; Cuzzocrea, S; Getting, S J; Zingarelli, B; Flower, R J; Salzman, A L; Perretti, M

Szabó, C; Lim, L H; Cuzzocrea, S; Getting, S J; Zingarelli, B; Flower, R J; Salzman, A L; Perretti, M.

Affiliation

Szabó C; Children's Hospital Medical Center, Division of Critical Care, Cincinnati, Ohio 45229, USA.

J Exp Med ; 186(7): 1041-9, 1997 Oct 06.

Article in En | MEDLINE | ID: mdl-9314553

Subject(s)

Inflammation/enzymology; Neutrophils/physiology; Poly(ADP-ribose) Polymerase Inhibitors; Animals; Benzamides/pharmacology; Carrageenan/pharmacology; Cell Movement/drug effects; Edema; Enzyme Inhibitors/pharmacology; Histocytochemistry; Inflammation/immunology; Lung/pathology; Male; Mice; Mice, Knockout; Multiple Organ Failure/enzymology; Multiple Organ Failure/immunology; Peritonitis/enzymology; Peritonitis/immunology; Poly(ADP-ribose) Polymerases/metabolism; Rats; Rats, Wistar; Zymosan/pharmacology

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Full text: 1 Database: MEDLINE Main subject: Poly(ADP-ribose) Polymerase Inhibitors / Inflammation / Neutrophils Limits: Animals Language: En Journal: J Exp Med Year: 1997 Type: Article Affiliation country: United States

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