Interleukin 7 transgenic mice develop chronic colitis with decreased interleukin 7 protein accumulation in the colonic mucosa.

Watanabe, M; Ueno, Y; Yajima, T; Okamoto, S; Hayashi, T; Yamazaki, M; Iwao, Y; Ishii, H; Habu, S; Uehira, M; Nishimoto, H; Ishikawa, H; Hata, J; Hibi, T

Watanabe, M; Ueno, Y; Yajima, T; Okamoto, S; Hayashi, T; Yamazaki, M; Iwao, Y; Ishii, H; Habu, S; Uehira, M; Nishimoto, H; Ishikawa, H; Hata, J; Hibi, T.

Affiliation

Watanabe M; Keio Cancer Center, School of Medicine, Keio University, Tokyo 160, Japan. mamoru@mc.med.keio.ac.jp

J Exp Med ; 187(3): 389-402, 1998 Feb 02.

Article in En | MEDLINE | ID: mdl-9449719

Subject(s)

Colitis/genetics; Interleukin-7/metabolism; Intestinal Mucosa/metabolism; Animals; Antigens, CD/immunology; Antigens, CD/metabolism; Blotting, Southern; Colitis/etiology; Colitis/immunology; Colitis/pathology; Cytokines/metabolism; Disease Models, Animal; Flow Cytometry; Gene Expression Regulation/genetics; Humans; Immunohistochemistry; Inflammation/immunology; Interleukin-7/genetics; Interleukin-7/pharmacology; Intestinal Mucosa/pathology; Lymphocytes/immunology; Lymphocytes/metabolism; Mice; Mice, Transgenic; Promoter Regions, Genetic/genetics; RNA, Messenger/analysis; RNA, Messenger/metabolism; Receptors, Interleukin/metabolism; Receptors, Interleukin-7; T-Lymphocytes, Helper-Inducer/immunology; T-Lymphocytes, Helper-Inducer/metabolism

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Full text: 1 Database: MEDLINE Main subject: Interleukin-7 / Colitis / Intestinal Mucosa Type of study: Etiology_studies / Prognostic_studies Limits: Animals / Humans Language: En Journal: J Exp Med Year: 1998 Type: Article Affiliation country: Japan

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