Effect of L-buthionine-(S,R)-sulphoximine, an inhibitor of gamma-glutamylcysteine synthetase on peroxynitrite- and endotoxic shock-induced vascular failure.

Cuzzocrea, S; Zingarelli, B; O'Connor, M; Salzman, A L; Szabó, C

Cuzzocrea, S; Zingarelli, B; O'Connor, M; Salzman, A L; Szabó, C.

Affiliation

Cuzzocrea S; Children's Hospital Medical Center, Division of Critical Care, Cincinnati, Ohio 45229, USA.

Br J Pharmacol ; 123(3): 525-37, 1998 Feb.

Article in En | MEDLINE | ID: mdl-9504394

Subject(s)

Buthionine Sulfoximine/pharmacology; Endothelium, Vascular/drug effects; Enzyme Inhibitors/pharmacology; Glutamate-Cysteine Ligase/antagonists & inhibitors; Nitrates/pharmacology; Shock, Septic/physiopathology; Animals; Aorta, Thoracic/drug effects; Aorta, Thoracic/physiology; Cell Survival/drug effects; Cells, Cultured; Endothelium, Vascular/cytology; Endothelium, Vascular/physiology; Enzyme Induction; Glutathione/physiology; Humans; In Vitro Techniques; Muscle Contraction/drug effects; Nitric Oxide Synthase/biosynthesis; Rats

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Database: MEDLINE Main subject: Shock, Septic / Endothelium, Vascular / Buthionine Sulfoximine / Enzyme Inhibitors / Glutamate-Cysteine Ligase / Nitrates Limits: Animals / Humans Language: En Journal: Br J Pharmacol Year: 1998 Type: Article Affiliation country: United States

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google