2-Methoxy-4-nitroaniline and its isomers induce cytochrome P4501A (CYP1A) enzymes with different selectivities in the rat liver.

Degawa, M; Nakayama, M; Konno, Y; Masubuchi, K; Yamazoe, Y

Degawa, M; Nakayama, M; Konno, Y; Masubuchi, K; Yamazoe, Y.

Affiliation

Degawa M; Faculty of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.

Biochim Biophys Acta ; 1379(3): 391-8, 1998 Mar 02.

Article in En | MEDLINE | ID: mdl-9545601

Subject(s)

Aniline Compounds/pharmacology; Cytochrome P-450 Enzyme System/biosynthesis; Microsomes, Liver/enzymology; Nitro Compounds/pharmacology; Animals; Cytochrome P-450 Enzyme System/genetics; Cytochrome P-450 Enzyme System/metabolism; Enzyme Activation/drug effects; Enzyme Induction/drug effects; Microsomes, Liver/drug effects; RNA, Messenger/biosynthesis; RNA, Messenger/drug effects; Rats; Rats, Inbred F344

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Database: MEDLINE Main subject: Microsomes, Liver / Cytochrome P-450 Enzyme System / Aniline Compounds / Nitro Compounds Limits: Animals Language: En Journal: Biochim Biophys Acta Year: 1998 Type: Article Affiliation country: Japan

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