Genetic evaluation of suspected cases of transient HIV-1 infection of infants.
Science
; 280(5366): 1073-7, 1998 May 15.
Article
in En
| MEDLINE
| ID: mdl-9582120
ABSTRACT
Detection of human immunodeficiency virus-type 1 (HIV-1) on only one or a few occasions in infants born to infected mothers has been interpreted to indicate that infection may be transient rather than persistent. Forty-two cases of suspected transient HIV-1 viremia among 1562 perinatally exposed seroreverting infants and one mother were reanalyzed. HIV-1 env sequences were not found in specimens from 20; in specimens from 6, somatic genetic analysis revealed that specimens were mistakenly attributed to an infant; and in specimens from 17, phylogenetic analysis failed to demonstrate the expected linkage between the infant's and the mother's virus. These findings argue that transient HIV-1 infection, if it exists, will only rarely be satisfactorily documented.
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Database:
MEDLINE
Main subject:
Specimen Handling
/
HIV Infections
/
HIV-1
Type of study:
Diagnostic_studies
Limits:
Female
/
Humans
/
Infant
/
Newborn
Language:
En
Journal:
Science
Year:
1998
Type:
Article
Affiliation country:
United States