Low molecular weight phosphotyrosine protein phosphatase translocation during cell stimulation with platelet-derived growth factor.
FEBS Lett
; 432(3): 145-9, 1998 Aug 07.
Article
in En
| MEDLINE
| ID: mdl-9720913
ABSTRACT
Low Mr phosphotyrosine protein phosphatase (PTP) is a cytosolic enzyme whose activity upon platelet-derived growth factor (PDGF) and insulin receptors has been demonstrated in vivo. In our study we demonstrate that this enzyme, both naturally expressed and overexpressed in NIH/3T3 fibroblasts, translocates from the cytosol to the Triton X-100 insoluble fraction following stimulation with PDGF. It emerges that the phosphorylation of a defined population of PDGF receptors, which is localized in this fraction and seems to be endowed with peculiar features and functions, is particularly affected by low Mr PTP overexpression.
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Database:
MEDLINE
Main subject:
Platelet-Derived Growth Factor
/
Protein Tyrosine Phosphatases
Limits:
Animals
Language:
En
Journal:
FEBS Lett
Year:
1998
Type:
Article
Affiliation country:
Italy