Arg89Cys substitution results in very low membrane expression of the Duffy antigen/receptor for chemokines in Fy(x) individuals.

Tournamille, C; Le Van Kim, C; Gane, P; Le Pennec, P Y; Roubinet, F; Babinet, J; Cartron, J P; Colin, Y

Tournamille, C; Le Van Kim, C; Gane, P; Le Pennec, P Y; Roubinet, F; Babinet, J; Cartron, J P; Colin, Y.

Affiliation

Tournamille C; INSERM U76, Institut National de la Transfusion Sanguine, Paris, France; the Centre National de Référence sur les Groupes sanguins, Paris, France; the Centre Régional de Transfusion Sanguine, Toulouse, France.

Blood ; 92(6): 2147-56, 1998 Sep 15.

Article in En | MEDLINE | ID: mdl-9731074

Subject(s)

Amino Acid Substitution/genetics; Antigens, Protozoan; Arginine/genetics; Carrier Proteins/biosynthesis; Cysteine/genetics; Duffy Blood-Group System/genetics; Membrane Proteins/biosynthesis; Protozoan Proteins; Receptors, Cell Surface/biosynthesis; Receptors, Chemokine/biosynthesis; Alleles; Animals; Blood Grouping and Crossmatching; Blotting, Western; COS Cells; Carrier Proteins/analysis; Carrier Proteins/genetics; Duffy Blood-Group System/biosynthesis; Humans; Isoantibodies/metabolism; Membrane Proteins/blood; Molecular Sequence Data; Mutation; Receptors, Cell Surface/analysis; Receptors, Cell Surface/genetics; Receptors, Chemokine/blood; Transcription, Genetic; Transfection

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Database: MEDLINE Main subject: Arginine / Carrier Proteins / Protozoan Proteins / Receptors, Cell Surface / Receptors, Chemokine / Amino Acid Substitution / Cysteine / Duffy Blood-Group System / Membrane Proteins / Antigens, Protozoan Limits: Animals / Humans Language: En Journal: Blood Year: 1998 Type: Article Affiliation country: France

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