Structure-activity relationship studies of dynorphin A and related peptides.

Naqvi, T; Haq, W; Mathur, K B

Naqvi, T; Haq, W; Mathur, K B.

Affiliation

Naqvi T; Division of Biopolymers, Central Drug Research Institute, Lucknow, India.

Peptides ; 19(7): 1277-92, 1998.

Article in En | MEDLINE | ID: mdl-9786179

ABSTRACT

ABSTRACT

An up-to-date review is presented covering all the available information concerning the isolation, discovery, synthesis, conformation, receptor binding characteristics, pharmacological properties and SAR studies of dynorphin A and related peptides. The potential of dynorphin A and its analogs has yet to be fully realized.

Subject(s)

Dynorphins; Analgesia; Animals; Cardiovascular System/drug effects; Dynorphins/chemistry; Dynorphins/isolation & purification; Dynorphins/metabolism; Dynorphins/pharmacology; Humans; Immune System/drug effects; Receptors, Opioid, kappa/metabolism; Structure-Activity Relationship

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Database: MEDLINE Main subject: Dynorphins Limits: Animals / Humans Language: En Journal: Peptides Year: 1998 Type: Article Affiliation country: India

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PubMed Links

Database: MEDLINE Main subject: Dynorphins Limits: Animals / Humans Language: En Journal: Peptides Year: 1998 Type: Article Affiliation country: India