Regulation of voltage-dependent K+ channels by methionine oxidation: effect of nitric oxide and vitamin C.
FEBS Lett
; 442(1): 48-52, 1999 Jan 08.
Article
in En
| MEDLINE
| ID: mdl-9923602
ABSTRACT
Methionine oxidation is known to alter functional properties of a transient A-type potassium channel expressed in Xenopus oocytes. We show here that nitric oxide (NO) slows down the K+ channel inactivation time course by oxidizing a critical methionine residue in the inactivation ball domain of the channel protein. We also demonstrate that the channel protein is protected from methionine oxidation by the enzyme methionine sulfoxide reductase and the antioxidant vitamin C.
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Database:
MEDLINE
Main subject:
Potassium Channels
Limits:
Animals
Language:
En
Journal:
FEBS Lett
Year:
1999
Type:
Article
Affiliation country:
United States