Emergence of aph(3')-VI and accumulation of aminoglycoside modifying enzyme genes in KPC-2-possessing Enterobacter aerogenes isolates from infections and colonization in patients from Recife-PE, Brazil
Rev. Soc. Bras. Med. Trop
; Rev. Soc. Bras. Med. Trop;52: e20180460, 2019. tab
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| ID: biblio-1041512
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ABSTRACT
Abstract INTRODUCTION:
The objective of this study was to characterize genes of aminoglycoside modifying enzymes (AMEs) in colonizing and infecting isolates of E. aerogenes harboring bla KPC from patients at a public hospital in Recife-PE, Brazil.METHODS:
We analyzed 29 E. aerogenes clinical isolates resistant to aminoglycosides. AMEs genes were investigated by PCR and sequencing.RESULTS:
Colonizing and infecting isolates mainly presented the genetic profiles aac(3)-IIa/aph(3')-VI or ant(2")-IIa/aph(3')-VI. This is the first report of aph(3')-VI in E. aerogenes harboring bla KPC in Brazil.CONCLUSIONS:
The results highlight the importance in establishing rigorous methods for the surveillance of resistance genes, especially in colonized patients.Palabras clave
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Bases de datos:
LILACS
Asunto principal:
Enterobacter aerogenes
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Farmacorresistencia Bacteriana
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Infecciones por Enterobacteriaceae
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Aminoglicósidos
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Antibacterianos
Límite:
Humans
País/Región como asunto:
America do sul
/
Brasil
Idioma:
En
Revista:
Rev. Soc. Bras. Med. Trop
Asunto de la revista:
MEDICINA TROPICAL
Año:
2019
Tipo del documento:
Article
País de afiliación:
Brasil