Antibody response against SARS-CoV-2 in convalescent plasma donors: Can we predict subjects' eligibility?
Hematol., Transfus. Cell Ther. (Impr.)
; 44(1): 1-6, Jan.-Mar. 2022. tab, graf
Article
en En
| LILACS
| ID: biblio-1364895
Biblioteca responsable:
BR408.1
Ubicación: BR408.1
ABSTRACT
Abstract Introduction As the Coronavirus Disease 2019 (COVID-19) pandemic unfolds around the world; answers related to the antibody response against the virus are necessary to develop treatment and prophylactic strategies. We attempted to understand part of the immune response of convalescent plasma donation candidates. Method We carried out a cross-sectional, observational, non-intervention study, testing 102 convalescent plasma donation candidates for antibodies against the virus, relating these data to the time interval between symptom onset and sample collection, age, disease severity, and gender. Results In our sample, the individuals who developed a greater antibody response were the ones who had a longer time interval between symptom onset and sample collection, the ones who had been hospitalized and the subjects above 35 years old. Moreover, 17 individuals did not present any reactive antibodies. Conclusion These results are important in that they raise questions about the role of the humoral response against the virus, as some individuals do not develop antibodies to fight it. In addition, they help develop recruitment strategies for convalescent plasma donors, who should be asymptomatic for at least 21 days and are possibly more likely to have reactive antibodies after 35 days without symptoms.
Palabras clave
Texto completo:
1
Bases de datos:
LILACS
Asunto principal:
Infecciones por Coronavirus
/
Prueba Serológica para COVID-19
/
COVID-19
Tipo de estudio:
Prognostic_studies
/
Risk_factors_studies
Límite:
Adolescent
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Adult
/
Female
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Humans
/
Male
Idioma:
En
Revista:
Hematol., Transfus. Cell Ther. (Impr.)
Asunto de la revista:
Hematologia
/
TransfusÆo de Sangue
Año:
2022
Tipo del documento:
Article
País de afiliación:
Brasil