Continuous flow Aza-Michael reaction for preparing the fast-acting synthetic opioid drug Remifentanil
Braz. J. Pharm. Sci. (Online)
; 59: e22764, 2023. graf
Article
en En
| LILACS
| ID: biblio-1439499
Biblioteca responsable:
BR40.1
Ubicación: BR40.1
ABSTRACT
Abstract Remifentanil is a modern fentanyl analogue with ultrashort-action granted by an esterase-labile methyl propanoate chain. Here, we present the development of a continuous flow methodology for the key N-alkylation step of remifentanil preparation in a biphasic, "slug-flow" regime. We screened parameters under microwave-assisted reactions, translated conditions to flow settings, and obtained remifentanil under 15-min residence time in a 1-mL microreactor, with a space-time yield of 89 mg/mL·h and 94% yield.
Palabras clave
Texto completo:
1
Bases de datos:
LILACS
Asunto principal:
Preparaciones Farmacéuticas
/
Remifentanilo
/
Analgésicos Opioides
Idioma:
En
Revista:
Braz. J. Pharm. Sci. (Online)
Asunto de la revista:
Farmacologia
/
Teraputica
/
Toxicologia
Año:
2023
Tipo del documento:
Article
País de afiliación:
Brasil